E-Pak®
E-Pak cartridges are radial flow adsorption cartridges developed specifically for pharmaceutical processing. Created with proprietary technology, E-Pak cartridges provide the rapid kinetics of fine particle adsorption at flow rates and capacities suitable for laboratory, pilot plant, and full-scale commercial operations. They are designed for use in both aqueous and organic solvent systems, and incorporate design features compatible with use in explosion proof environments.
- Proven cartridge design assures simple, reliable adsorption processes with excellent scalability from bench scale to full commercial production
- Fixed porous media completely eliminates handling and safety issues associated with loose carbon
- Large adsorption capacity in a small footprint increases product recovery and reduces solvent requirement
- RETROFIT KITS available to allow cartridge use in most existing filter housings
Applications: E-Pak adsorbent cartridges are designed for the purification of API’s and intermediates dissolved in polar and nonpolar solvents. Primary applications include removal and recovery of catalyst, reaction-by-products and color from synthetic reaction mixtures and natural products. Compared to loose media, prepacked columns and ventricular style filters, Graver Process Scale Adsorbents provide important advantages including: Reduced process time, increased purity and recovery, improved safety, handling disposal, and lower operating cost.
E-Pak adsorbent cartridges are available in a range of sizes and formulations (based on many of the adsorbent formulations in our Ecosorb C-Series of adsorbents) to accommodate the broad range of processing requirements encountered over the typical API development cycle.
Graver supplies filter housings for the complete range of cartridge sizes and configurations available, and will also supply retrofit kits for many commonly used filter housings. Contact Graver for complete details.
Downloads
- GTX 323 E-Pak® Process Scale Adsorbent Cartridge
- GTX 324 Operating Procedure for E-Pak® Lab-Scale Housing and Adsorbent Cartridges
- GTX 325 Pilot Plant and Commercial Scale Housings for E-Pak® Process Scale Adsorbent Cartridges (Coming soon – contact your Graver representative for our most recent information)
- GTX 327 E-Pak® Adsorbent Cartridge Selection Guide for Pharmaceutical Applications (Coming soon – contact your Graver representative for our most recent information)
E-Pak® Media and Laboratory Scale Cartridges
| E-PAK Formula* |
Active Adsorbent | Available Sizes | Media Weight |
|---|---|---|---|
| C-941 | Carbon-Wood-Acid Activated | Loose Media 5 cm Diameter x (1 ,10 & 25 cm High) Cartridges |
100 grams 5, 50 & 125 grams respectively |
| C-944 | Carbon-Coal Steam Activated | ||
| C-947 | Carbon-Wood-Acid Activated | ||
| C-950 | Flash Silica |
*Custom Formulations Available
E-Pak® Pilot Scale Cartridges
| E-PAK Formula | Active Adsorbent | Available Sizes | Media Weight |
|---|---|---|---|
| C-941 | Carbon-Wood-Acid Activated | 16.5 Diameter x 12.5 cm and 25 cm High Cartridges with DOE or 222 O-ring Seal | 0.85 Kg |
| C-944 | Carbon-Coal Steam Activated | ||
| C-947 | Carbon-Wood-Acid Activated | 1.7 Kg | |
| C-950 | Flash Silica | ||
E-Pak® Commercial Scale Cartridges
| E-PAK Formula | Active Adsorbent | Available Sizes | Adsorbent Weight |
|---|---|---|---|
| C-941 | Acid Activated Carbon | 16.5 Diameter x 50 cm High Cartridge with DOE or 222 O-ring Seal | 3.4 Kg |
| C-944 | Steam Activated Carbon | ||
| C-947 | Acid Activated Carbon | 16.5 Diameter x 100 cm High Cartridge with DOE or 222 O-ring Seal | 6.8 Kg |
| C-950 | Flash Chromatography Grade Silica |
E-Pak® Flow, Hydraulic Pressure Drop, and Contact Time
| Cartridge Size | Flow Rate | Pressure Drop (?P- ATM) with 1 cps fluid | Contact Time (Minutes) |
|---|---|---|---|
| Lab Scale(5cm D x 1, 5 & 10 cm H Cartridge) | 7 - 37 - 75 mL/min | 0.07 | 2.5’ |
| Pilot & Commercial Scale (16.5 cm D x 12.5 25, 50, 100 cm H Cartridge) | 0.95- 1.9 - 3.8 - 7.6 L/min | 0.17 | 2.5’ |
E-Pak® Custom Cartridge Housings
| # Cartridges | Description | Materials of Construction |
|---|---|---|
| 1 | 10" or 20" housing dome, T-Style , 222 O-ring Seal | 316L SS or Hastelloy® C-276 |
| 3 | 20" or 40" housing dome, T-Style, 222 O-ring Seal | |
| 7 | 20" or 40" housing dome, T-Style, 222 O-ring Seal | |
| 12 | 30” or 40” housing dome, T-Style, 222 O-ring Seal |
Filter Housing Options: ASME or PED Pressure Rated/Stamped, Conductive Casters, KALREZ® Gaskets, Type and Size of Inlet & Outlet, Wetted and Non-Wetted Surface Finish.
Hastelloy®is a registered trademark of Haynes International
KALREZ®is a registered trademark of E.I. du Pont de Nemours